The 2022 Challenge Cup final will take place at the Tottenham Hotspur Stadium on 28 May as it moves from its traditional Wembley home.
Wembley has hosted most finals since 1929, with the event briefly moving to the Principality Stadium and Twickenham during redevelopment in the 2000s.
The final will move back across north London and return to Wembley in 2023.
"We are delighted to bring yet another major sporting event to our stadium," said Spurs chairman Daniel Levy.
The final is reverting to a May date, having been staged in August from 2005 to 2019.