Tottenham Hotspur and Manchester City will both have 2,000 fans at Wembley for the Carabao Cup final on 25 April.
But fans under 18 cannot attend, and people who are clinically extremely vulnerable or pregnant have also been told not to apply for tickets.
To get into Wembley, fans must take a lateral flow coronavirus test at a designated site - not at home - in the 24 hours before the game.
And they must bring proof of a negative result, either a text or an email.
Fans who get a ticket must sign a consent form, as the match is part of the government's events research programme, which is assessing how major events can reopen safely to the public as coronavirus restrictions ease.