Burnley striker Ashley Barnes faces a spell on the sidelines after tearing a muscle in his thigh.
James Tarkowski and Ashley Westwood are suspended after both picked up their fifth booking of the season last week.
Tottenham head coach Antonio Conte made nine changes for Thursday's Europa Conference League defeat by NS Mura.
Oliver Skipp has returned from suspension and may be one of very few to keep their place from midweek. Cristian Romero remains out.
LAWRO'S PREDICTION
Antonio Conte has made a strong start at Spurs with four points from his first two games in charge and he will know exactly what to expect at Turf Moor.