Leeds remain without six players because of injury, including key midfielder Kalvin Phillips.
Fit-again defender Diego Llorente, who returned to the match-day squad against Wolves, could make his first appearance for a month.
Southampton boss Ralph Hasenhuttl says midfielder Stuart Armstrong has a "50-50" chance of recovering from a muscle problem in time to play on Tuesday.
Kyle Walker-Peters, Theo Walcott and Ibrahima Diallo are still sidelined.
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