Apoel Nicosia manager Giorgos Donis believes his defenders will know what to expect from Tottenham striker Harry Kane given they have already faced Lionel Messi and Cristiano Ronaldo.
Kane has been in irresistible form in recent weeks, scoring eight goals in his last six matches, including two in Spurs' win over Borussia Dortmund.
Another Champions League victory in Cyprus on Tuesday would put Mauricio Pochettino's side in a strong position to qualify from Group H, particularly given Dortmund must take on Real Madrid the same evening.
Apoel were beaten 3-0 by Madrid in their opening game, with Ronaldo scoring twice, while three years ago they went up against Messi and Neymar at Barcelona.