Tottenham manager Antonio Conte says football's governing bodies are "not worried" about player welfare.
Cristian Romero, Richarlison and Son Heung-min will miss Spurs' match at home to Liverpool on Sunday because of injuries that could also keep them out of the World Cup.
The Premier League breaks a week before the World Cup starts, on 20 November, and resumes seven days after the final.
"This type of schedule is crazy," said Conte.
"Many times I hear about the welfare of the players, but they are not really worried about the welfare of the players if the schedule is this.