Tottenham will be without Eric Dier, Oliver Skipp and Japhet Tanganga for Wednesday's visit of Southampton – but deadline day duo Dejan Kulusevski and Rodrigo Bentancur could be handed their full debuts for the club.
Dier, who has not played since January 23, is struggling with a recurring thigh issue and has not recovered in time for Saints' visit to the Tottenham Hotspur Stadium on Wednesday.
Antonio Conte also confirmed that Skipp will miss out with a groin problem while Tanganga has been ruled out with a knee injury.