Ange Postecoglou defended his decision to make nine changes after Tottenham suffered a penalty shoot-out defeat at Fulham in the Carabao Cup second round.
Spurs entered this contest following back-to-back wins in the Premier League, which had generated a feelgood factor around the club despite the departure of all-time top scorer Harry Kane on the eve of the new season.
Only Micky van de Ven and Richarlison retained their starting berths from the win at Bournemouth and while Tottenham improved from a sluggish start, penalties were required after a 1-1 draw and Davinson Sanchez failed to score from 12 yards to hand the visitors a 5-3 spot-kick loss.