The Toronto Maple Leafs have five regular players out of their lineup – almost 30% of their lineup – so there are no guarantees, but its starting to approach a sure thing.
The odds that the Leafs make it are extremely high.

Odds vary, but I’ve seen them as high as 87%.
Toronto Maple Leafs Playoff Odds
The Leafs have 17 games remaining, including tonight’s match against the Vancouver Canucks.
They currently hold a four point lead over the Panthers for third in the Atlantic, and Florida has 18 games left.