They recently renewed The Simpsons for two more seasons, which will bring them to 28. But the big news is that Harry Shearer will not be a part of the cast. Shearer voiced Ned Flanders, Charles Montgomery Burns, Waylon Smithers, Seymour Skinner, Dr. Hibbert, Lenny Leonard, Kent Brockman, Scratchy, Kang, Eddie, Otto Mann, Rev. Lovejoy, Rainier Wolfcastle, Jasper, Dr. Marvin Monroe and many, many others. It's a rather significant loss.
At this point, The Simpsons has gone on so long, there's a whole generation of people like me who grew up worshipping the show and have grown incredibly indifferent over time.