Right-hander Marco Estrada was officially reinstated from the 15-day disabled list Friday, and he will start the Blue Jays' series opener against the Mariners at Rogers Centre.
Left-hander Franklin Morales also was reinstated from the DL, while lefty Aaron Loup and infielder Andy Burns were optioned to Triple-A Buffalo. Right-hander Dustin Antolin was designated for assignment to make room for Morales on the 40-man roster.
Morales, 30, has been limited to just two-thirds of an inning this season because of shoulder trouble. He allowed two runs in 11 innings over 11 appearances during his rehab stint.