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Ready for the madness to begin? The 2021 men's NCAA tournament kicks off Thursday night with the First Four, which brings two No. 11 seed matchups (including two bluebloods facing off) and two No. 16 matchups for the right to advance to the first round. Normally held in Dayton, this year's First Four will be held at the homes of Indiana (Assembly Hall) and Purdue (Mackey Arena).