Week 16 got underway with Thursday night's AFC West showdown between the Denver Broncos and Los Angeles Chargers. The two rivals were battling for positioning ahead of the NFL playoffs. Fantasy managers, meanwhile, are looking to stay alive in their own postseasons.
While there are no more bye weeks to navigate in the 2024 season, managers must still contend with injuries, unfavorable matchups and tough lineup decisions.
Here, you'll find a look at look at some of the toughest matchups remaining in Week 16, along with start-sit advice based on past performances, player health and projected roles.