Both the Bills and Saints are coming off losses, and looking for a win in Thursday night’s Thanksgiving game.
- Moneyline: Buffalo (-275) | New Orleans (+225)
- Spread: Buffalo -6.5 (-110) | New Orleans +6.5 (-110)
- Total: 45.5 -Over (-110) | Under (-110)
- Game Info: Nov. 25, 2021 | 8:20 p.m. ET | Fox
Buffalo is favored by 6.5, and it should be. Buffalo has Josh Allen and one of the league’s top defenses. The Saints have second-string QB Trevor Siemien under center, and a defense that has surrendered the fourth-most passing yards (1,098) and the second-most passing touchdowns (8) to enemy QBs across their last four contests.