The Week 1 fantasy football waiver wire isn't dissimilar from trying to find sleepers in fantasy drafts.
Difference being, there is typically a four-week buffer of work put in by the players in time for the waiver wire. All fantasy owners will have access to the same highlight reels and such though, so the trick is finding a way to utilize all the data available to carve out some long-term success.
It sounds dramatic, but the first waiver wire can make or break a season. Unearthing a running back in Week 1 who goes on to get year-round usage means finding a guy who probably should have been drafted in the first round of most leagues, so it's a critical process the best owners will attempt to exploit.