Caleb Williams and the Trojans are 2-point favorites over the Green Wave.
A pair of 11-2 teams meet on Jan. 2 in the Cotton Bowl when No. 8 USC meets No. 14 Tulane. USC enters the game as a 2-point favorite.
Southern Cal looked poised to be in the College Football Playoff after going 11-1 to start the year, with its only loss coming to conference rival Utah by one point (43-42). The Trojans led the Pac-12 in scoring (534 points), which covered up some of the weakness on defense (363 points allowed – eighth in the conference).