In the first of two Monday night games this week, the Tennessee Titans are likely to be overmatched as they head to Highmark Stadium in Buffalo. The Bills remain the Super Bowl favorites at SISB at +550 after coming out sharp in their first week of play, crushing the reigning Super Bowl champion Rams, 31-10, and easily covering the -2.5 point spread in that one. The Titans, meanwhile, dropped their Week 1 matchup to the Giants, despite being -5.5 point favorites.
- Moneyline: Titans (+350) | Bills (-450)
- Spread: Titans +9.