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The 12-seeds for Bettors to Target Against 5-Seeds in March Madness

With Selection Sunday now in the books, it is time to fill out your brackets.

Arguably one of the most popular picks every year by college basketball fans is determining which No. 12 seeds will upset the No. 5 seeds.

Why, you ask?

History.

Seventeen 12-seeds have knocked out the stronger seeded 5-seeds since 2010, and we have witnessed this upset take place against multiple teams - in the same tournament - a whopping five times spanning the last 11 tournaments!

LM Otero/AP

Discovering that No. 12 seeds have emerged victorious at a 39% clip in 44 matchups over that span, bettors and those filling out their brackets need to take notice.