Two NFC South teams dealing with suspensions to key players will square off in New Orleans on Sunday when the Saints host the Tampa Bay Buccaneers as huge home favorites at the sportsbooks.
The Buccaneers are without starting quarterback Jameis Winston for the first three games because he violated the NFL's personal conduct policy while the Saints will not have running back Mark Ingram for four games due to PEDs.
NFL point spread: The Saints opened as seven-point favorites; the total was 52 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 33.