8:25 p.m. Eastern, NFL Network
The Buccaneers became a respectable team far faster than most predicted, but coming off a loss, they will need to win out to have a realistic chance of making the playoffs. That journey begins with a trip to St. Louis to face a team that runs the ball well and always seems to make opposing teams work hard on offense.
For Tampa Bay to win this game, it will need Jameis Winston to continue his rapid development as a quarterback while also giving the ball to Doug Martin more often.