Slovakia may sit in second place, a point above Wednesday's opponent, but Spain will still enter as the favorite to win at home in Sevilla and qualify for the knockout stage.
La Furia Roja have underperformed at the Euros so far with a pair of draws against group leader Sweden, which has already clinched its spot in the round of 16, and Poland, against whom Álvaro Morata scored his side's only goal of the tournament so far.
Spain does come into the group finale on a 10-match unbeaten streak—although six of the 10 games have ended in draws.