Russell Wilson leads the professional rivalry with Cam Newton five games to two, with Seattle going 4-3 against the spread over the last seven meetings with Carolina. In a key game in the NFC playoff picture the Seahawks play the Panthers on Sunday afternoon in Charlotte.
NFL point spread: The Panthers opened as three-point favorites; the total was 45 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 26.5-22.2 Panthers (NFL picks on every game)
Check out the OddsShark podcast on iTunes or Spotify or at OddsShark.