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Seahawks-49ers NFC Wild-Card Odds, Spread, Lines and Best Bet

The 49ers are favored by more than a touchdown at home against the Seahawks for their wild-card game. The 49ers swept the regular-season games.

The second-seeded 49ers (13-4) host NFC West division rival and the seventh-seeded Seahawks (9-8) on Saturday afternoon in a wild-card matchup.

The Niners were favored and easily covered the spread in both regular-season games. Jimmy Garoppolo got the win in Week 2, while rookie Brock Purdy led San Francisco to a Week 15 victory. Both games went under the SI Sportsbook total.

Despite using three starting quarterbacks this season, the Niners don’t seem to be missing a beat.