In the spirit of "any given Sunday" and with two large upsets last week NFL double-digit underdogs are 3-1 both straight up and against the spread this season. The San Francisco 49ers, now down to their backup quarterback, take a turn as a double-digit dog for their road meeting with the Los Angels Chargers on Sunday afternoon.
NFL point spread: The Chargers opened as 9.5-point favorites; the total was 47 early in the week, according to sportsbooks monitored by OddsShark. (Line updates and matchup report)
NFL betting pick, via OddsShark computer: 28.