MELBOURNE, Australia — In one of the biggest upsets in Australian Open history, Novak Djokovic, a six-time champion in the tournament, was defeated in five sets in the second round by Denis Istomin, a wild card from Uzbekistan ranked 117th in the world.
With Istomin’s stunning 7-6 (10-8), 5-7, 2-6, 7-6 (7-5), 6-4 victory, Djokovic, ranked No. 2, suffered his earliest defeat in a Grand Slam tournament in nearly nine years.