The only undefeated team in the NFC is one of the biggest Week 7 favorites.
San Francisco opened as a 10-point favorite for its cross-country trip to face Washington, who broke its winless start Sunday.
The last time Washington was a double-digit underdog at home, it failed to cover against New England, who itself possesses a large line.
In fact, the pair of AFC East games in Week 7 have two of the three highest spreads, with Buffalo and the Patriots favored by a combined 26.5 points.
However, underdogs could continue to be the betting story after nine won in Week 6.