Four perennial contenders in the AFC square off in two of Week 1's top Sunday matchups, with Pittsburgh visiting New England and Indianapolis taking on the Los Angeles Chargers.
The Colts, Patriots and Steelers are tasked with replacing key parts of their offense, while the Chargers might have to do the same if Melvin Gordon is still holding out.
The Chargers and Patriots are two of six home teams favored by five points or more in Week 1.
Week 1 Schedule and Predictions
Predictions against the spread in bold.
Thursday, September 5
Green Bay at Chicago (-3)
Sunday, September 8
Los Angeles Rams (-3) at Carolina
Washington at Philadelphia (-8.