8:25 p.m. Eastern CBS, NFL Network
Line: Texans by 1
Four weeks into the season, the A.F.C. South appears to be the weakest division in the N.F.L. The good news for the Indianapolis Colts and the Houston Texans — two teams that have disappointed greatly after entering the season with playoff aspirations — is that the division looks up for grabs. Somebody has to win it.
The Colts have dominated it of late, compiling 15 straight wins against A.F.C. South foes. Whether they can make it 16 will largely be determined by the status of quarterback Andrew Luck, who sat out Sunday’s 16-13 overtime victory over the Jacksonville Jaguars with a partial shoulder separation.