Three division titles and one wild-card spot are left up for grabs in Week 18.
The AFC North will be decided on Saturday, while the NFC South and NFC North will be figured out the following day.
The lone wild-card spot left open is in the AFC, where the Denver Broncos need a win to clinch and eliminate the Miami Dolphins and Cincinnati Bengals.
Sunday's marquee game is the last one, as the Detroit Lions and Minnesota Vikings do battle for the NFC North crown and the No. 1 overall seed in the NFC.
Both teams own a tiebreaker over the Philadelphia Eagles, so the final game of the NFL regular season comes with high stakes.