Five of the six wild-card round games are set going into Sunday night of Week 18.
Two of those matchups in the AFC are expected to swing well in favor of the two home teams.
The Buffalo Bills and Baltimore Ravens are the two biggest favorites on the wild-card round point spread at DraftKings Sportsbook.
The three other set matchups contain spreads of four points or less, including one road favorite.
Jim Harbaugh's Los Angeles Chargers are a road favorite in Houston and they should be a popular bet based on the current form of both teams.