Saquon Barkley's career was going very well.
He was one of the most hyped running back prospects ever out of Penn State. Even if no running back should go second overall anymore in the modern NFL, at least he was a blue-chip player. The New York Giants didn't regret the pick in 2018, when Barkley had 2,028 total yards and won NFL Offensive Rookie of the Year. Barkley had a good follow-up season in 2019 as well, though injuries limited him a bit.
Then in 2020 Barkley tore his ACL, and he hasn't been the same since.