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NFL Picks Week 4: Expert Predictions, Odds Guide and Over-Under Lines

Week 4 of the NFL season gets underway Thursday night, when a pair of NFC contenders square off at the Los Angeles Coliseum.

As it does on a regular basis, the quarterback position will be under a microscope, with this weekend's focus shining on the rookie class.

Cleveland's Baker Mayfield and Arizona's Josh Rosen join Buffalo's Josh Allen and the New York Jets' Sam Darnold in the starting ranks after making appearances in Week 3.

The other quarterbacking storyline comes out of San Francisco, where C.J. Beathard takes over for the 49ers after Jimmy Garoppolo's injury.