The Arizona Cardinals (1-3) already have as many losses as they did all of the 2015 regular season, and they will try to avoid falling again Thursday night when they visit the San Francisco 49ers (1-3) as four-point road favorites on the NFL point spreads at sportsbooks monitored by OddsShark.com.
The Cardinals are likely to be without starting quarterback Carson Palmer due to a concussion, with Drew Stanton expected to take his place at San Francisco.
Palmer was injured late in the fourth quarter of a 17-13 home loss to the Los Angeles Rams last Sunday, with Stanton taking over and throwing two interceptions on 11 pass attempts with only four completions to his own team.