Which conference is responsible for the only No. 16 seed to win a game in NCAA tournament history? That would be the America East, of course. That accomplishment came in 2018 when the UMBC Retrievers knocked off the Virginia Cavaliers, who entered the tournament as the top overall seed.
However, if things go according to plan in the America East tournament, its representative won't be a 16-seed this time around. The Vermont Catamounts are one of the more intriguing teams from the mid-major conferences and will surely be a popular pick when people are filling out their brackets come mid-March.