Saturday's Michigan-Iowa game has been canceled due to COVID-19 issues, the Wolverines announced on Tuesday.
The two schools were slated to face off as part of the Big Ten's Champions Week.
Michigan athletic director Warde Manuel said the program had more than 50 players unavailable to play compared to the previous week.
With Saturday's game being canceled, Michigan's season is over.
The Wolverines (2-4) will end the 2020 season winless at home and with only two wins for the season. It also marks the program's first losing season since going 5-7 in 2014 under coach Brady Hoke.