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March Madness 2025: Which low seeds have the best chances of pulling a huge first-round upset?

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5 min read

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Will the 2025 men’s NCAA tournament produce a massive upset? The odds of it happening may be better than you think.

Five of the last six NCAA tournaments have included at least one No. 1, No. 2 or No. 3 seed losing in the first round. And that stretch includes two No. 16 over No. 1 upsets.

In 2018, UMBC made tournament history with its win over No. 1 Virginia. In 2021, No. 15 Oral Roberts beat No. 2 Ohio State and No.