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Louisville's Reyne Smith re-injures his ankle in March Madness and leaves court with towel over head

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Louisville guard Reyne Smith (6) is helped off the court due to injury against Creighton during the second half in the first round of the NCAA college basketball tournament, Thursday, March 20, 2025, in Lexington, Ky. (AP Photo/Brynn Anderson)

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LEXINGTON, Ky. (AP) — Louisville guard Reyne Smith tried to play through an injured right ankle that kept him out of the Cardinals' last four games.

With 11:37 left in the Cardinals' first-round NCAA Tournament game on Thursday, his ankle gave way and Smith collapsed into the fetal position, likely ending his March Madness run.