Closing out a trio of NFL Week 16 Saturday contests, San Francisco hosts Los Angeles at 8:15 p.m. ET on Dec. 21, 2019, at Levi's Stadium in Santa Clara, CA. The 49ers are fighting for first place in the NFC West while the Rams are clinging to slim Wild Card playoff hopes.
Spread: 49ers -6.5 (-110) | Rams +6.5 (-110)
Moneyline: 49ers (-270) | Rams (+230)
Total: OVER 45 (-110) | UNDER 45 (-110)
Rams’ Season to Date
Los Angeles (8-6) heads into this contest following a 44-21 loss to the Cowboys in Dallas last week.