Liverpool can move closer to the Premier League title when the leaders face Fulham on Sunday.
Manchester City will look to bolster their bid to qualify for the Champions League against arch rivals Manchester United, while Southampton bid to stave off relegation.
AFP Sport looks at three talking points ahead of the weekend's action:
Van Dijk issues Liverpool challenge
Virgil van Dijk has challenged Liverpool to out-work the teams that stand between the Reds and a record-equalling 20th English title.
Arne Slot's side had to dig deep to beat Everton 1-0 in a tetchy Merseyside derby at Anfield on Wednesday.