defensive end will miss Sunday's game against the .
The Chargers listed Bosa, who was limited in practice Wednesday, Thursday and Friday, as out with a concussion and shin injury.
The 25-year-old earned his third Pro Bowl nod this season with 7.5 sacks, 39 tackles and 27 quarterback hits through 12 games on a mediocre defense that's allowing an average of 345.1 yards per game and 27.8 points heading into Week 16.
Bosa entered the concussion protocol following the team's Week 8 loss to the Denver Broncos. He returned for a Week 11 victory over the New York Jets.