Connacht and Munster welcome back Irish internationals for the United Rugby Championship interprovincial showdown at MacHale Park on Saturday (14:30 GMT).
The hosts bring in Mack Hansen, Bundee Aki, Finlay Bealham and captain Cian Prendergast for what will be the first time a professional Connacht game is held in County Mayo, and the first time rugby is played at the Castlebar venue in its 95-year history.
The Ireland quartet are among seven Connacht changes from the 43-40 defeat by Ospreys in Wales.
Chay Mullins, Jordan Duggan and Sean Jansen also come into the starting XV.