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Giants RB Saquon Barkley ruled out vs. 49ers with ankle injury

New York Giants running back Saquon Barkley has been ruled out for Thursday's game against the San Francisco 49ers with an ankle injury.

Barkley injured his ankle in Sunday's comeback win over the Arizona Cardinals. He limped to the bench during the final drive of New York's 31-28 win and was later revealed to have sustained an ankle sprain.

ESPN's Adam Schefter reported Monday that Barkley was expected to miss three weeks after the results of his MRI. Head coach Brian Daboll declined Tuesday to rule him out for Thursday's game, calling Barkley a "quick healer.