Your heart may have dropped all the way into your stomach when Jimmy Garoppolo was running down the sidelines in NFL Week 3 and his ACL gave way before the quarterback was hit or stepped out of bounds.
That injury hit a number of fantasy owners hard, as did tight end Delanie Walker's ankle injury that will keep him out until Week 10, if not longer.
Perhaps your team was affected by earlier injuries to wide receiver Marqise Lee (knee) of the Jacksonville Jaguars or Garoppolo's teammate running back Jerick McKinnon (ACL).
You'll need to go after new blood to keep your fantasy team afloat.