This is as good of a matchup as you’ll find in Week 1. Cook faces the Cardinals, who may have the worst defensive line in football. Cook is coming off a season where he earned nearly 1,600 total yards and now gets to follow that up with a matchup against a defensive line whose personnel would likely be backups on most other teams.
The Bills are six-point favorites and projected to score a strong 27 points this week. Cook has an increased chance to score a touchdown in this game. Start him with confidence.