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A players-to-drop column will never be one-size-fits-all, so season these recommendations to taste with the size and scope of your league.
Patrick Mahomes, QB, Chiefs (99%)
Normally I don't include injured players in this column because what's the point? You know what to do. But I suspect many fantasy managers will have trouble cutting bait with the dinged Mahomes (ankle) because of the name-brand value.