Mikel Arteta marked his first European game as Arsenal manager with a 1-0 victory at Olympiakos in the first leg of their round-of-32 meeting in the Europa League on Thursday.
Manchester United was held to a 1-1 draw at Club Brugge while Inter Milan had an easier time at Ludogorets in Bulgaria, with Christian Eriksen scoring his first goal for the Italian club in a 2-0 win.
Another Premier League side, Wolverhampton Wanderers, cruised to a 4-0 win over Espanyol thanks to a hat trick by Diego Jota and a spectacular long-range volley by Ruben Neves.
Winning the Europa League may be the best chance for all three Premier League teams to book a spot the lucrative Champions League next season.