While the 2025 NCAA tournament has been chock full of favorites, it was the underdog Houston Cougars who provided the most shocking upset Saturday night, defeating Duke 70-67 and ending the game on a 9-0 run. The result was a massive win for sportsbooks, both from a single-game and futures perspective, as many bettors had parlayed the Florida moneyline and Duke moneyline together, and Duke was by far the biggest title liability at sportsbooks across the country.
The other semifinal saw Florida overcome a double-digit second-half deficit to defeat No. 1 seed Auburn 79-73 and cover the spread as a 2.