Andrew Smith, who helped put Butler University in the national spotlight as a member of two Final Four teams that twice reached the N.C.A.A. championship game as admired underdogs, died on Tuesday in Indianapolis after a two-year struggle with cancer. He was 25.
Barry Collier, Butler’s athletic director, announced Smith’s death in a joint statement with the university president, James Danko.
Smith, who was 6-foot-11, played on Butler’s national runner-up teams in 2010 and 2011 and finished his career with 1,147 points and 648 rebounds.
He learned he had an aggressive form of non-Hodgkin lymphoma early in 2014.