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49ers vs. Chiefs: Historic Head-to-Head Record and Super Bowl 58 Pick

The San Francisco 49ers and Kansas City Chiefs will face each other for just the fourth time since 2015 in Super Bowl 58.

Two of those meetings, including the one next Sunday in Las Vegas, are Super Bowl matchups.

Kansas City triumphed in the last Super Bowl meeting in 2020 to mark the start of Patrick Mahomes' championship-winning era.

The Chiefs have been back to the Big Game on two other occasions, while the 49ers are back for the first time since their loss to Kansas City in Miami.

San Francisco has not defeated the Chiefs in any head-to-head meeting in a decade, and a win in Las Vegas would not only be sweet because it dethroned the Chiefs, but because it would reward the 49ers with a long-awaited title under Kyle Shanahan.