The Toledo-Eastern Michigan series is a one-sided affair, with the Rockets owning an all-time record of 38-13 against the Eagles.
Eight of Eastern's 13 wins have come in Ypsilanti, the site for Saturday's game.
Chris Creighton only has two victories over Toledo, but the series has been more competitive than the win-loss column has shown. Five of the past seven meetings have been decided by five points or less.
The Rockets are currently an 8½-point favorite for Saturday's game.
"The beauty of early November football is there's another big game waiting for you again this Saturday," Toledo coach Jason Candle said.